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Biswa Ranjan Meher

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Biswa Ranjan Meher

Dr. Biswa Ranjan Meher

Designation: Asst. Professor and Coordinator

Qualification: Ph.D. in Biotechnology with specialization in Computational Biology and Bioinformatics, 2009, Indian Institute of Technology, Guwahati (IITG), Assam, India.

Phone No.: 9686697197

ORCID: https://orcid.org/0000-0003-0519-9074

VIDWAN ID: 166978

Google Scholar ID: Qb8favoAAAAJ

E-mail ID: brm.bot@buodisha.edu.in, brmeher@gmail.com

Biosketch

Dr. Biswa Ranjan Meher received his M. Sc. degree from Utkal University-Bhubaneswar with Biochemistry as specialization. He qualified national level entrance examinations CSIR-NET and GATE to pursue Ph. D. in Biotechnology at Indian Institute of Technology, Guwahati (IITG) under the supervision of Dr. Pradipta Bandyopadhyay....

Subsequently, he worked as a Post-Doctoral Researcher at different US universities like the University of Kansas (KU), Kansas; Albany State University (ASU), Georgia; and University of Richmond (UR), Virginia. He also worked as a DS Kothari Post-Doctoral Fellow (DSKPDF) in the Department of Biochemistry at the Indian Institute of Science, Bangalore, India from 2014 to 2016. Before joining to his current position, he also served as an Assistant Professor in the DBT-BUILDER Programme at the Centre for Life Sciences, Central University of Jharkhand, Ranchi, India from 2016 to 2017. He has worked in several collaborative interdisciplinary research areas in USA, and in India. He is a recipient of National Doctoral Fellowship by AICTE, Govt. of India. Dr. Meher has expertise in Computational Biology and Bioinformatics and his research area focus on molecular modelling and simulations of biomolecules of therapeutic importance, structure based drug and vaccine design, pharmacologically bioactive natural products, development of Nano-medicine and their applications, understanding the protein conformations through structure network analysis, and application of computational tools to solve biological problems. His laboratory welcomes interested candidates to carry out research work in Molecular modelling and simulations of biomolecules and its applications in drug design and discovery.

  • Computational Biology & Structural Bioinformatics,
  • Structure based drug and vaccine design,
  • Protein structure network and dynamics study,
  • Computer simulations and Molecular Modeling,
  • Virtual Screening and drug discovery,
  • Nano-medicine development and applications

  • Assistant Professor, (Nov, 2017 – Till Date) at PG Department of Botany, Berhampur University, Odisha, India.
  • Guest Faculty,(Aug 2020- March, 2021) at Department of Biosciences & Bioinformatics, Khallikote University, Berhampur, Odisha, India.
  • Visiting Professor,(Fall Session 2020) at Department of Biological Sciences, IISER Berhampur, Odisha, India.
  • Assistant Professor, DBT-BUILDRER Project, (Feb, 2016 – Oct, 2017) at Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi, India.
  • DS Kothari Post-Doctoral Fellow (DSKPDF)(July, 2014 to Feb, 2016) at Department of Biochemistry, & Molecular Biophysics Unit, IISc, Bengaluru, India.
  • Post-Doctoral Research Scientist (March, 2013 to March 2014) at Computational and Theoretical Chemistry Laboratory, Department of Chemistry, University of Richmond, Virginia, USA.
  • Post-Doctoral Research Associate (May, 2010 – Feb, 2013), at the Computational Chemistry Laboratory, Department of Natural Sciences, Albany State University, Albany, Georgia, USA.
  • Post-Doctoral Research Associate(April, 2009 – April, 2010), at the Center for Bioinformatics and Structural Biology Center, University of Kansas, Lawrence, KS, USA.
  • Junior Research Fellow (July, 2004 – Dec, 2004), at the Regional Plant Resource Centre, Bhubaneswar, Orissa, India.

  • Purohit, D. Barik, J. Dansana, & B.R. Meher* (2024). Investigating Lycotoxin-An1a (An1a), a defense antiviral peptide from Alopecosa nagpag venom as prospective anti-dengue agent against DENV-2 NS2B-NS3 protease. Computational Biology and Chemistry, 108: 108005 (IF 3.10)
  • Nayak, R. Raju, P. Das, K. Das, A. Suvitha, R. Meher, S. E. Alobid, A. I. Almoteer, M. E. Almadani, A. Alshehri, A. Alghamdi, F. Ahmad, S. I. Rabbani, S. M. Basheeruddin Asdaq, N. Nayeem, (2024) Novel Ibuprofen prodrug: A possible promising agent for the management of complications of Alzheimer’s disease. Saudi Pharmaceutical Journal, 32 (1): 101888. (IF 4.10)
  • Purohit, P.S. Sahoo, M.Panda, K. Kabasi, S.K. Senapati & B.R. Meher* (2023). Evaluating the antiviral potential of phytocompounds from Mesua ferrea against SARS-CoV-2 Main protease: Structure-based virtual screening and Molecular Dynamics simulation investigations. ChemistrySelect (IF 2.10) (In Press)
  • Purohit, M. Panda, J.T. Muya, P. Bandyopadhyay & B.R. Meher* (2023). Theoretical insights into the binding interaction of Nirmatrelvir with SARS-CoV-2 Mpro mutants (C145A and C145S): MD simulations and Binding Free-energy calculation to understand drug resistance. Journal of Biomolecular Structure and Dynamics (IF 4.40) (In Press)
  • Purohit, D. Barik, S. Agasti, M. Panda, & B.R. Meher* (2023). Evaluation of the inhibitory potency of anti-dengue phytocompounds against DENV-2 NS2B-NS3 protease: Virtual screening, ADMET profiling and molecular dynamics simulation investigations. Journal of Biomolecular Structure and Dynamics (IF 4.40) (In Press)
  • Purohit, S. Patel*, and B. R. Meher* (2023) In silico analysis of the conserved protein domain kelch in bacteria to understand its role in pathogenesis. Research Journal of Berhampur University (RJBU), 4: 24-28.
  • K. Murmu, M. Panda, B.R. Meher, P. Purohit, J. Behera and T. K. Barik* (2023) Molecular Surveillance of Kelch-13 gene in Plasmodium falciparum field isolates from Mayurbhanj District, Odisha, and in silico Artemisinin-Kelch-13 protein interaction study. Parasitology Research, 122: 717–727. (IF 2.383)
  • Purohit, J.J. Dash, J. T. Muya, and B. R. Meher* (2023) Molecular insights to the binding interactions of APNS containing HIV-protease inhibitors against SARS-CoV-2 Mpro: An in silico approach towards drug repurposing. Journal of Biomolecular Structure and Dynamics 41 (9): 3900–3913 (IF 4.40)
  • Purohit, S. Sahoo, M. Panda, P.S. Sahoo, and B. R. Meher* (2022) Targeting the DENV NS2B-NS3 protease with active antiviral phytocompounds: Structure-based virtual screening, molecular docking, and molecular dynamics simulation studies. Journal of Molecular Modeling, 28 (11): 1-20. (IF 2.172)
  • Panda, P. Purohit, Y. Wang and B. R. Meher* (2022) Functionalized Carbon Nanotubes as an alternative to traditional anti-HIV-1 protease inhibitors: An understanding towards Nano-medicine development through MD simulations. Journal of Molecular Graphics and Modeling, 117: 108280. (IF 2.942)
  • Panda, P. Purohit, and B. R. Meher* (2022) Structure-based virtual screening, ADMET profiling, and molecular dynamics simulation studies on HIV-1 protease for identification of active phytocompounds as potential anti-HIV agents. Molecular Simulation, 48 (11): 1031-1049. (IF 2.346)
  • J. Dash, P. Purohit, J. T. Muya, and B. R. Meher* (2020) Drug repurposing of allophenylnorstatine containing HIV-Protease inhibitors against SARS-CoV-2 Mpro: Insights from molecular dynamics simulations and binding free energy estimations. ChemRxiv.: Preprint publication.
  • K. Panda, S. Patra, P. P. Naik, P. P. Praharaj, S. Mukhopadhyay, B. R. Meher, P. K. Gupta,S. Verma, T. K. Maiti, S. K. Bhutia*. (2019) Deacetylation of LAMP1 drives lipophag dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. Journal of Cellular Physiology. 235: 2776-2791. (IF 6.513)
  • Mahto, R. Tripathy, B.R. Meher, B. Prusty, M. Sharma, D. Deogharia, A.K. Saha, A.K. Panda*, B. Das*. (2019) TNF-α promoter polymorphisms (G-308A and G-238A) are associated with susceptibility to SLE and P. falciparum malaria: a study in malaria endemic area. Scientific Reports. 9 (1): 11752. (IF 4. 996)
  • T. Muya*, B. R. Meher, S. C. Sahoo, H. Chung. (2019) A Theoretical insight into the role of counter anions and their interactions in Nitrotropentaamminecobalt(III) towards Linkage Isomerism induced photochemical motion. International Journal of Quantum Chemistry.  119 (14), e25929 (IF 2.437)
  • Sinha, B.  R. Meher, P. P. Naik, P.  K.  Panda, T. K. Maiti, S.K. Bhutia*. (2019) p73 induction by Abrus agglutinin facilitates Snail ubiquitination to inhibit epithelial to mesenchymal transition in oral cancer. Phytomedicine. 55, 179-190. (IF 6.656)
  • Patel*, Ahmad Homaei, B Raju Akondi, B.R. Meher. (2018) Estrogen: The necessary evil for human health and ways to tame it. Biomedicine & Pharmacotherapy. 102, 403-411. (IF 7.419)
  • K. Panda, P. P. Naik, P. P. Praharaj, B. R. Meher, P.K. Gupta, R.S. Verma, T. K. Maiti, M. K. Shanmugam, A Chinnathambi, S. A. Alharbi, G Sethi, R Agarwal, S. K. Bhutia*. (2018) Abrus agglutinin stimulates BMP2 dependent differentiation through autophagic degradation of β-catenin in colon cancer stem cells. Molecular Carcinogenesis. 57 (5), 664-677. (IF 5.139)
  • K.  Panda, P. P. Naik, B.  R. Meher, D.  N. Das, S.  Mukhopadhyay, P. P Praharaj, T. K. Maiti, S.K. Bhutia*. (2018) PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. BBA – Molecular Cell Research. 1865, 480-495 (IF 5.011)
  • N. Das, P. P. Naik, S.  Mukhopadhyay, P.  K.  Panda, N.  Sinha, B.  R. Meher, S.K. Bhutia*. (2017) Elimination of dysfunctional mitochondria through mitophagy suppresses Benzo[a]pyrene-induced apoptosis. Free Radical Biology and Medicine. 112, 452-463. (IF 8.101)
  • Patel*, A. Rauf, and B. R. Meher (2017) In silico analysis of ChtBD3 domain to find its role in bacterial pathogenesis and beyond. Microbial Pathogenesis.110, 519-526 (IF 3.848)
  • Patel*, A. Rauf, H. Khan, B. R. Meher, S. Shams ul Hassan. (2017) A holistic review on autoimmune disease vitiligo with emphasis on the causal factors. Biomedicine & Pharmacotherapy. 92, 501-508. (IF 7.419)
  • K. Panda, B. Behera, B.R. Meher, D.N. Das, S. Mukhopadhyay, N. Sinha, P.P. Naik, B. Roy, S. Paul, T.K. Maiti, S.K. Bhutia* (2016) Abrus agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death. Molecular Carcinogenesis. 56 (2), 389-401. (IF 5.139)
  • Patel* and B.R. Meher. (2016) A review on emerging frontiers of house dust mite and cockroach allergy research. Allergologia et Immunopathologia. 44 (6): 580-593 (IF 2.094)
  • R. Meher*, A. Dixit, G. Bousfield, G.H. Lushington* (2015). Glycosylation effects on FSH-FSHR interaction dynamics: A case study of different FSH glycoforms by Molecular Dynamics simulations. Plos One. 10(9): e0137897 (IF 3.752)
  • R. Meher, and Yixuan Wang* (2015). Exploring the drug resistance of V32I and M46L mutant HIV-1 protease to inhibitor TMC114: Flap Dynamics and binding free energy studies. Journal of Molecular Graphics and Modeling, 56, 60 -73 (IF 2.942)
  • R. Meher*, M. V. Satish Kumar, and Pradipta Bandhyopadhyay (2014). Interchain hydrophobic clustering promotes rigidity in HIV-1 Protease flap dynamics: New insights from Molecular Dynamics. Journal of Biomolecular Structure and Dynamics, 32, 899-915 (IF 5.235)
  • Zhen-feng Xu,R. Meher, Darnashley Eustache and Yixuan Wang* (2014). Insight into the interaction of DNA bases and defective graphenes: Covalent or Non-covalent. Journal of Molecular Graphics and Modeling, 47, 8-17 (IF 2.942)
  • R. Meher, and Yixuan Wang* (2012). Binding of Single walled carbon nanotube to WT and mutant HIV-1 proteases: Analysis of flap dynamics and binding mechanism. Journal of Molecular Graphics and Modeling, 38,430-445. (IF 2.942)
  • R. Meher*, M. V. Satish Kumar, Smriti Sharma and Pradipta Bandhyopadhyay (2012). Conformational dynamics of HIV-1 Protease: A comparative molecular dynamics simulation study with multiple AMBER force fields. Journal of Bioinformatics and Computational Biology, 10 (06): 1250018. (IF 1.204)
  • R. Meher, and Yixuan Wang* (2012). Interaction of I50V mutant and I50L/A71V double mutant to HIV-1 protease inhibitor TMC114 (Darunavir): Molecular Dynamics and Free energy studies. Journal of Physical Chemistry B, 116:1884-1900. (IF 3.466)
  • R. Meher, M. V. Satish Kumar and Pradipta Bandhyopadhyay* (2009). Molecular Dynamics simulation of HIV-protease with polarizable and non-polarizable force fields. Indian Journal of Physics, 83, 81-90 (Special issue in simulation) (IF 1.778)
  • Bandhyopadhyay* and B. R. Meher, (2006). Drug resistance of HIV-1 protease against JE2147: I47V mutation investigation by molecular dynamics simulation. Chemical Biology and Drug Design, 67:155-161. (IF 2.873)

List of Book Chapters:

  • Sanjeev, S. Kaushik, B.R. Meher*, MVS Kumar* (2018). Disorder in Proteins. Reference Module in Life Sciences. (ELSEVIER). Editor: Shobha Ranganathan, (Chapter # 20271) ISBN: B978-0-12-809633-8.20271-9 (In Press).
  • R. Meher*, Megha Vaishnavi, Seema Patel, MVS Kumar, S. Kausik, (2019). Mutation effects on 3D-structural reorganization using HIV-1 protease as a case study. Encyclopedia of Bioinformatics and Computational Biology. (ELSEVIER). Editor: Shobha Ranganathan. 2018, pp. 3: 706-721.  ISBN: B978-0-12-811414-8.20279-4.
  • R. Meher*, and Seema Patel (2013). Structural and dynamical aspects of HIV-1 protease and its role in drug resistance. Advances in Protein Chemistry and Structural Biology, Vol 92, Dynamics of Protein and Nucleic Acids, Tatyana Karabencheva-Christova (Editor) Academic Press, 2013, pp. 299-324. ISBN: 978-0-12-411636-8.  (IF 5.447)

List of Conference Proceedings:

  • R. Meher*, M. V. Satish Kumar and Kausik Sen (2008). Pressure induced conformational dynamics of HIV-1 protease: A Molecular Dynamics Simulation study. IEEE Computer Society, pp.118-122 doi:10.1109/ICIT.2008.39.
  • K. Acharya, B.R. Meher, A.K. Mukherjee (2004) Application of ISSR markers among crop species. In Proc. 8th Orissa Bigyan Congress. Bhubaneswar Chapter. Regional Plant Resource Centre, Bhubaneswar, Orissa, India, Dec 11-12th, 2004. pp. 76-82.

Sl.No.Title of the Sponsored projectDurationAmount Sanctioned (INR)Funding AgencyStatus
1Discovering phytochemicals as antiviral agent against HIV-1 protease to combat drug-resistance: A multi-faceted in silico approach2 Years10.00 LakhsUGC,Govt. of India.
Completed
2Exploring Phytocompounds as anti-viral agents against Dengue NS2B-NS3 Protease: A multi-faceted in silico approach.3 Years10.00 LakhsScience & Technology Dept., Govt. of Odisha.Completed

  • Cell Biology, Biophysical Chemistry, Biochemistry, General Biology, Bioinformatics, Computational Biology, Nano-biotechnology, Environmental Biology, Anatomy of Plants.

  • Awarded the APJ Abdul Kalam Smruti Samman from Meher Samaj at village Laumunda, Odisha in Aug, 2016.
  • Awarded the DS Kothari Post- Doctoral Fellowship by UGC, Govt. of India for Research and development in May 2014.
  • Qualified National Eligibility Test (June-2003) for Lectureship conducted jointly by Council of Scientific and Industrial Research and University Grant Commission, India (CSIR/UGC-NET).
  • Qualified the National level examination, Graduate Aptitude Test in Engineering in Life Sciences (GATE-2004) with 85.48 Percentile.
  • Awarded the prestigious National Doctoral Fellowship by AICTE, New Delhi, Govt. of India for research and development during Ph.D. program in 2006.

Number of doctoral thesis supervising: 04

  • Madhusmita Panda
  • Priyanka Purohit
  • Jarmani Dansana
  • Abhishikta Gadtya

Number of M.Phil. Dissertations supervised: 01

  • Saubhagya Subhadarshini Sahoo – Natural product (Maslinic Acid) as anti-HIV agent: A computational approach.

Number of M.Sc. Dissertations supervised/Co-supervised: 22

  • Subhashree Biswal – Binding mechanism of prospective drug JE-2147 to 147V mutant HIV-1 protease: An in-silico approach to study drug resistance.
  • Srikanta Kumar Swain – Phytocompound cyanin as a prospective agent against HIV-1 protease: An in-silico approach.
  • Shradha Mahato – Exposing the phytocompound Berberine as a prospective inhibitor for the HIV-1 protease: An in silico
  • Harapriya Behera – Exploring the phytocompound Stigmasterol as possible Anti-HIV agent against HIV-1 protease: A computational approach.
  • Kiran Jyoti – Inhibitors against Chikungunya Virus Screening of potent phytochemicals against CHIKV NSP2 protease: A computational approach.
  • Suchismita Swain – Computational approach towards exploring potential Anti-CHIKV of selected natural compounds (Quercetin & Luteolin).
  • Bishnupriya Routaray – In silico Exploration of Phytocompounds from Pluchea lanceolata and phyllanthus Emblica as potential therapeutics against CHIKV NSP2 protease.
  • Manisha Marndi – Exploring the phytocompound Afzelin as possible anti-Covid agent against SARS-Cov-2 Mpro: A computational approach.
  • Partha Sarathi Sahoo – Exploring the phytocompounds Baicalin as possible anti-Covid agent against SARS-CoV-2 Main protease (Mpro): A Computational approach.
  • Sonali Das – Exploring the phytocompound Isorhapontigenin as a possible anti-Covid agent against SARS-COV-2 Main protease: A Computational approach.
  • Jaishree – Understanding the role of human USP46 in the regulation of TLR4 mediated immune response of macrophages.
  • Debasish Barik – An in-silico characterization, Modelling and binding interaction of Lectin-Legume-LecRK-Arcelin-ConA domain containing alpha-amylase inhibitor against gut amylase of bruchid (Callosobruchus Chinensis) in pigeon pea.
  • Suraj Kumar Nahak – Phytochemical analysis and pharmacological evaluation of methanolic flower and leaf extract of Calotropis gigantea over the bronchial inflammation (Asthma).
  • Swopna Simron Parija – An in-silico characterization, modelling and binding interaction for evaluation of inhibitory potency of Anti Dengue algal compounds against DENV-2 NS2B-NS3pro
  • Rupali Nath – Computational Exploration of antiviral activity of algal compounds against NS2B-NS3 protease of Dengue virus: Virtual screening, ADMET profiling and Molecular Dynamics Simulation investigation.
  • Rojalin Pradhan – Uncovering the therapeutic efficacy and probable drug resistance of TESTOSTERONE a phytocompound against SAR-Cov-2 Main protease: MD simulation and Binding free energy estimation analysis.
  • Pratikshya Prajnajyoti Das – Screening of potent algal compounds as anti-CHIKV agents against NSP2 Protease of Chikungunya virus: An in-silico approach.
  • Swati Swagatika Behera: Investigation of Inhibitory effects of algal compounds against CHIKV NSP2 protease: An in-silico approach.
  • Shraddha Priyadarshini – Inhibitors against chikungunya virus screening of potent algal compounds against CHIKV NSP2 protease: A computational approach.
  • Laxmipriya Das – An in-silico approach towards drug discovery against the SAR-COV-2 Mpro and evaluation of the inhibitory efficacy of anti-COVID phytocompounds (Catechin): MD simulation and binding free energy estimation analysis.
  • Kshitismayee Mohanty – Uncovering the therapeutics efficacy and probable drug resistance of Apigenin a phytocompounds against SAR-Cov-2 Main protease: MD simulation and binding free energy estimation analysis.
  • Abhishikta Gadtya – Evaluation of Inhibitory potency of Anti-Dengue algal compounds against NS2B-NS3 protease: in-silico

Number of M.Sc. Dissertations supervising: 07

  • Gobinda Chandra Pradhan
  • Jayanti Sethi
  • Rajeswari Priyadarshini
  • Ritu Choudhury
  • Ruchismita Patra
  • Sugyani Padhy
  • Usasi Pradhan

  • PROTEINS: Structure, function and Bioinformatics (WILEY publishers).
  • Journal of Computational Biology and Bioinformatics Research (Academic Journals).
  • International Journal of Biological Macromolecules. (Elsevier)
  • Mini-Reviews in Medicinal Chemistry. (Bentham Science)
  • Molecular Simulation (Taylor and Francis)
  • Scientific Reports (Nature Publishing Group)
  • Computers in Biology and Medicine, (Elsevier)
  • Journal of Biomolecular Structure and Dynamics (Taylor and Francis)
  • Molecular Diversity (Springer)
  • Journal of Physical Chemistry B (ACS)