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Laxmidhar Rout

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Laxmidhar Rout

Prof. (Dr.) Laxmidhar Rout

Designation: Assistant Professor

Qualification: Ph.D., IIT Guwahati, PDF: USA, Germany and France

Phone No.: 8658959639

ORCID: https://orcid.org/0000-0002-1432-2559

VIDWAN ID: https://vidwan.inflibnet.ac.in/profile/115653

Google Scholar ID: https://scholar.google.co.in/citations?user=7yqC1SsAAAAJ&hl=en

E-mail ID: Email:ldr.chem@buodisha.edu.in

Biosketch

Dr. Laxmidhar Rout was born in Basudevpur, Bhadrak (Odisha) in 1976. Dr. Rout, has completed a Master of Science (MSc) at Utkal University with synthetic organic chemistry as a specialization under the guidance of Prof. Satyaban Jena. ...

He completed his Ph.D. under the supervision of Prof. Punniyamurthy at IIT (Guwahati) in 2008. He has had very good experience in organic synthesis (anti-cancer, anti-malaria molecule synthesis, and asymmetric synthesis) during his postdoctoral studies in the USA (Prof. A. M. Harned; University of Minnesota; Prof. C. G. Zhao; University of San Antonio, Texas), Technical University, Munich, Germany (Prof. S. M. Huber); and the Institute of Curie, France (Dr. Ludger Johannes and Dr. B. Emmanuel). He has been awarded the prestigious Alexander von Humboldt Fellowship in Germany and the FPGG and IC Fellowship of France at the Institute of Curie Cancer Centre, Paris. Dr. Rout is now an UGC-Assistant Professor at Berhampur University, Odisha. Dr. Rout has more than nine years of teaching experience with postgraduate students at Berhampur University, and he worked as visiting faculty at IISER Berhampur from 2019–2021. He has published more than 40 research articles with high impact factors in Wiley, Elsevier, RSC, and ACS journals. He has active collaborations with Indian scientists as well as international scientists.
For details, visit: https://ldrout.in/

Synthetic Organic Chemist. Chemical Biology, Drug Discovery (Cancer, Malaria and Crop Protection); Synthetic Organic Chemistry, Methodology based total synthesis of small anti-cancer molecule, Analgesics, fungicides, C-H Activation; Stereo selective Synthesis, Synthesis of Heterocyclic, Sustainable organic chemistry in water.

2014-cont.UGC-Asst. ProfBerhampur University
2019-2021Visiting FacultyIISER Berhampur
2013-2014PostdoctorateInstitute of Curie, France
2011-2013PostdoctorateTUM, Munich, Germany
2010-2011PostdoctorateUniv. Sanantonio, Texas, USA
2008-2010PostdoctorateUniv. of Minnesotta, USA

TEXT BOOKS :

  • Prof. Satyaban Jena and Dr. Laxmidhar Rout, Name reaction, Rearrangments and Mechanism; Problem Solving Approach, 2024; ISBN NO: 978-81-19907-53-3, Indu Book Service Private Limited, New Delhi -110002
  • Prof. Satyaban Jena and Dr. Laxmidhar Rout, Pericyclic and Photochemistry; Problem Solving Approach, 2024; ISBN NO: 978-81-19907-91-5; Indu Book Service Private Limited, New Delhi -110002
  • Prof. Satyaban Jena and Dr. Laxmidhar Rout, Advanced Organic Spectroscopy ; Problem Solving Approach, 2024, ISBN NO: 978-81-19907-76-2, Indu Book Service Private Limited, New Delhi -110002
  • Prof. Satyaban Jena and Dr. Laxmidhar Rout, Reagent and Mechanism in Organic Synthesis; Problem Solving Approach, 2024; ISBN NO: 978-81-19907-48-9; Indu Book Service Private Limited, New Delhi -110002
  • Prof. Satyaban Jena and Dr. Laxmidhar Rout, Retrosynthesis and application; Problem Solving Approach, 2024; ISBN NO: 978-93-91-377-78-6; Indu Book Service Private Limited, New Delhi -110002.
  • Prof. Satyaban Jena and Dr. Laxmidhar Rout, Stereochemistry, Conformations and Asymmetric Synthesis ; Problem Solving Approach, 2024 ISBN NO: 978-81-19907-67-0, ISBN NO: 978-81-19907-67-0, Indu Book Service Private Limited, New Delhi -110002.
  • 42. Prof. Satyaban Jena and Dr. Laxmidhar Rout, General Organic Chemistry ; Problem Solving Approach, 2024. ISBN NO: 978-81-19907-72-4, Indu Book Service Private Limited, New Delhi -110002

Journals:

  • . A Novel Bimetallic BaCu2O3 Catalyst for  Csp2-O Cross-Coupling Reactions of Phenols with Arylhalide ,   Subhalaxmi Panda, ,  Pradyota  Kumar Behera,   Papita Behera,   Amlan Swain,  Amit Kumar Pradhan  and Prof. Dr. Laxmidhar Rout,  Chemistry Select 2023, 8, e202302445, https://doi.org/10.1002/slct.202302445.  IF 2.8
  • Transition Metal Catalyzed C-O Cross-coupling at Room Temperature,  *, Res. J. Berham. Univ. Papita Behera, P. K. Behera, A. Swain, A. K. Pradhan, Smruti S. Jena,and L.  Rout, Res. J. Berham. Univ 2023, 5, 90-95, ( ISSN 2250-1681), https://www.buodisha.edu.in/?p=submenupagecontent&pg=148
  • t-BuOH Solvent for CuSeO3 CatalyzedCsp2-SeCross-coupling of Diaryldiselenide with Arylhalides and Boronic acids,   A. K. Pradhan,  P.  K. Behera,  P. Choudhury, P. Behera,   A. Swain,  P.  Bag,  D. Pany,  and L. Rout,  Chemistry Select 2023, 8, e202300378   , https://doi.org/10.1002/slct.202300378 , 2.8
  • Immunomodulatory and anti-inflammatory and anticancer activities of porphyran, a sulfated galactan,  B.  Pradhan,  J.-S.  Ki  and L. Rout, Carbohydrate Polymers, 2023,, 301, Part A, 120326  (IF 11.0)  https://doi.org/10.1016/j.carbpol.2022.120326
  • CuMoO4 Catalyzed  Csp 2-Se Cross-Coupling of Aryl Bromide and Iodide with Diaryldiselenides in Water; P Choudhury,  A. K. Pradhan, S. Jena, B. K.  Sahoo, S. K. Sahu, P.  K. Behera, P. Behera,  A. Swain,and L. Rout , 2022, Eur. J. Org. Chem 2022, 48, e202201194, https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202201194.  IF 3.2
  • Transition Metal Catalysed C-S Cross-Coupling Reactions at Room Temperature.,   P. K. Behera,P. Choudhury P. Behera, A. K. Swain,A.  K. Pradhan, and L.  Routa*   Chemistry Select 2022, 7, 41, e202202919, https://doi.org/10.1002/slct.202202919, IF  2.8
  • MTP18 inhibition triggers mitochondrial hyperfusion to induce apoptosis through ROS-mediated lysosomal membrane permeabilization-dependent pathway in oral cancer;  D. P. Panigrahi, S. Patra, B. P. Behera, P. K. Behera, S. Patil, B.S. Patro,L.  Rout,,I. Sarangi , S. K. Bhutia,  Free Radical Biology and Medicine,  2022,  2022, 190, 307. https://doi.org/10.1016/j.freeradbiomed.2022.08.019, IF 8.1
  • Efficient Oxygen Bridged Bimetallic CuSeO3.2H2O Catalyzed (CSP2-CSp) Sonogasira Cross-Coupling of  Terminal Aryl Acetylene with Haloarenes, S. K. Sahu,P. Choudhury,and. L. Rout et al, New. J. Chem, 202246, 1650-1657, https://pubs.rsc.org/en/content/articlelanding/2022/nj/d1nj04485k, IF 3.9
  • Strategy for Synthesis of Structural Analogues of Artemisinin,  S.K. Sahu, P. K. Behera, M. C. Maity, P. Behera, A. Swain, R. K. Sahu, S. Panda and L. Rout, Res. J. Berham. Univ. 2021, 3, 69-82, 2021, ISSN 2250-1681
  • Recent advance in [3+2] cycloaddition of allene with 1,3-carbonyl ylide; Rh(II) catalyzed access to bridged polyoxocarbocyles;S. K. Sahu, and L. Routet al, New. J. Chem,2021, 45, 11018-11029, 10.1039/D1NJ02034J, IF 3.6
  • Oxygen bridged bimetallic CuMoO4nanocatalyst;  [Cu-O-Mo] for dehydrogenative benzylic alcohol  oxidation and DFT  study, P.K. Behera, and Prof. L. Rout et al, A. J. Org. Chem. 2021  10, 1117-1122  , 10.1002/ajoc.202100192, IF3.5
  • Efficient oxygen bridged bimetallic CuSeO3.2H2O catalyzed dehydrogenative oxidation of benzylic alcohol. P. Choudhury,and Prof. L. Routet al New. J. Chem,2021, 45, 5775-5779,  https://doi.org/10.1039/D1NJ00712B, IF 3.9
  • Recent Advances in Transition-Metal-Mediated Csp2-B and Csp2-P Cross-Coupling Reactions, L. Rout, T. Punniyamurthy, Coordination Chemistry Review,2021,  431, 213675, https://doi.org/10.1016/j.ccr.2020.213675, IF 26
  • 28, Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics,   S.  Patra; B. Pradhan; R.  Nayak; C.  Behera; L. Rout, M. Jena, T. Efferth, S. K. Bhutia,  Seminars in Cancer Biology, 2021, 73, 310-320, https://doi.org/10.1016/j.semcancer.2020.10.010 , IF 17
  • Developments in chemistry and biological application of cotarnine & its analogs ” S. K. Sahu,  P.K. Behera, P. Choudhury,  S.Panda, L.  Rout,  Tetrahedron 2020, 76,50, 131663,  https://doi.org/10.1016/j.tet.2020.131663, IF 2.8
  • Strategy and Problems for Synthesis  of Antimalaria Artemisinin (Qinghaosu), S. K. Sahu,  P.K. Behera, P. Choudhury,  S.Panda, L. Rout,  Chemistry Select, 2020,  29, 12333-12344, https://doi.org/10.1002/slct.202002885, IF  1.8
  • Bimetallic  BaMoO4 Nanoparticle for  C-S Cross-Coupling of Thiols  with Haloarene, S. Panda, R.; Panigrahi, P. Behera, S. Sahu, L. Rout, New J.  Chemistry, 2020, 44, 2500-2504. 10.1039/C9J05581A.  IF 3.9
  • CuMoO4 Bimetallic Nanoparticles, An  Efficient Catalyst for Room Temperature C-S Cross-coupling of Thiols and Haloarenes; R. Panigrahi, S. Panda, P. Behera, S. Sahu, L. Rout, Chem.- Eur. J, 2020, 26, 620 , 10.1002/chem.201904801, IF 5.7
  • Recyclable Bimetallic CuMoO4 Nanoparticle for  C-N Cross-Coupling Reaction Under Mild Condition , R. Panigrahi, S. Panda, P. Behera, S. Sahu, L. Rout, New J.  Chemistry,2019   43, 19274, 10.1039/C9NJ04436A, 3.1
  • Synthesis of of acyl derivatives of cotarnine, L. Rout, B. Emmanuel, A.  K. Sahoo, Org. Synth,  2018, 95, 455, 10.15227/orgsyn.095.0455, IF  1.5
  • Metal Free Activation of C(SP3)-H Bond, Practical and Rapid Synthesis of Privileged 1-Substituted-1,2,3,4-Tetrahydroisoquinolines, L. Rout, , J.-C.  Florent,  L.  Johannes, S.  K.  Choudhury, P. Rout, E. Bertounesque, Eur J. Org. Chem  2017,  35, 5275-5292 , 10.1002/ejoc.201700471 , IF 2.9
  • Metal-Free Activation of a C(sp)−H Bond of Aryl Acetylenes, L. Rout,. J.-C. Florent,  L.  Johannes, S.  K.  Choudhury, J.  Scanlon,  E. Bertounesque, Chem. – Eur. J. 2016, 22,14812–14815, 10.1002/chem.201603003, IF 5.7
  • Activation of a Carbonyl Compound by Halogen Bonding S. H. Jungbauer, F. Kniep, S.M. Walter, S. Schinder,  L. Rout, S. M. Huber;  Chem. Cumm, 2014, 50, 6281, 10.1039/C4CC03124E  IF  6.6
  • Multidentate Halogen-Bond Donors as Lewis Acidic Activators or Catalystsin Halide Abstraction Reactions, S. H. Jungbauer, F. Kniep, S.M. Walter, S. Schinder, L. Rout, S. M. Huber;  Synlett, 2013, 24, 20, 2624-2628, 10.1055/s-0033-1338981, IF 2.3
  • 5-Iodo-1,2,3-triazolium-based multidentate halogen-bond donors as activating reagents, F. Kniep, L. Rout, S.M. Walter, H. K. V. Bensch, S. H. Jungbauer, E. Herdtweck, S. M. Huber, Chem. Comm,2012, 48, 9299, 10.1039/C2CC34392D, IF 6.6
  • Synthesis of Isothermal Calorimetric Titrations on Charge-Assisted Halogen Bonds: Role of Entropy, Counter ions, Solvent, and Temperature, S. M. Walter, F. Kniep, L. Rout, F. P. Schmidtchen, E. Herdtweck, S. M. Huber, J. Am. Chem. Soc.2012, 134, 8507, 10.1021/ja2119207, IF 16
  • Synthesis of -Arylphosphonates Using Copper-Catalyzed -Arylation and Deacylative -Arylation of -Ketophosphonates. , L. Rout, S. Regati and C. G. Zhao, Adv. Synth. Catal. 2011, 353, 3340, 10.1002/adsc.201100605, 5.9
  • Organocatalytic Highly Enantioselective Synthesis of -Formyl-hydroxyphosphonates; S. Perera, V. K. Naganaboina, L.Wang, B. Zhang, Q. Guo, L. Rout, C.-G. Zhao;  Adv. Synth. Catal.2011, 353, 1729. 10.1002/adsc.201000835, 5.9
  • Axial Chiral Allenes as Dipolarphiles in Rh-Catalyzed Carbonyl Ylide Cycloaddition. L. Rout and A. M. Harned.,Chem. Eur. J. 2009,15, 12926. 10.1002/chem.200902208, 5.6
  • CuO Nanoparticles Catalyzed C−N, C−O, and C−S Cross-Coupling Reactions: Scope and Mechanism, S. Jammi, L. Rout, S. Sakthivel, T. Mukherjee, S. Mandal, R. Mitra, P. Saha, T. Punniyamurthy, J. Org. Chem. 2009, 74, 1971. 10.1021/jo802425310.1021/jo8024253, IF 4.5
  • Synthesis, Structure, and Application of Self-Assembled Copper(II) Aqua Complex by H-Bonding for Acceleration of the Nitroaldol Reaction in Water , S. Jammi, Md A. Ali, S. Sakthivel, L. Rout, T. Punniyamurthy , Chem. Asian. J.2009,4, 314-320. 10.1002/asia.200800339, IF  4.1
  • Synthesis, Crystal Structure and Application of Chiral Copper(II) Polymers for Asymmetric Acylation of Secondary Alcohols. S. Jammi, L. Rout, P. Saha, V. K. Akhilagunta, S. Sanyasiand T. Punniyamurthy, Inorg. Chem.  2008, 12, 5093, DOI:  10.1021/ic800228c. IF 4.5
  • Efficient Ligand-Free Nickel-Catalyzed C-S Cross-Coupling of Thiols with Aryl Iodides, . S. Jammi, P. Barua, L. Rout, P. Saha, T. Punniyamurthy, Tetrahedron. Lett.2008, 49,1484. 10.1016/j.tetlet.2007.12.118, IF 2.5
  • Efficient Copper(I) Catalyzed C-S Cross-Coupling of Thiols with Aryl Halides in Water; L. Rout, P. Saha, T. Punniyamurthy, Eur. J. Org. Chem.2008, 4, 640-643. 10.1002/ejoc.200700978, IF 2.8
  • Recent Advances in Copper-Catalyzed Oxidation of Organic Compounds. T. Punniyamurthy , L. Rout, Coord. Chem. Rev.2008, 252, 134.  10.1016/j.ccr.2007.04.003, IF 26
  • Cadmium(II) Catalyzed C-N Cross-Coupling of Amines with Aryl Iodides. L. Rout, S. Jammi,T. Punniyamurthy, Adv. Synth. Catal.2008, 350, 395.  10.1002/adsc.200700480, IF  5.25
  • Efficient CuO Nanoparticle Catalyzed C-S Cross Coupling of Thiols with Iodobenzene; L. Rout, T. K. Sen and T. Punniyamurthy, Angew. Chem. Int. Ed. Eng2007, 46, 5583. 10.1002/ange.200701282, IF 16
  • Novel CuO Nanoparticle Catalyzed C–N  Cross-Coupling of Amines with Iodobenzene.; lL. Rout, S. Jammi,  T. Punniyamurthy,  Org. Lett.2007, 9, 3397.   10.1021/ol0713887, IF 6.2
  • Chiral Linear Polymers Bonded Alternatively with Salen and 1,4-Dialkoxy-2,6-diethynylbenzene: Synthesis and Application to Diethylzinc Addition to Aldehydes. S. Jammi, L. Rout and T. Punniyamurthy, Tetrahedron: Asymmetry2007,17,2016. 10.1016/j.tetasy.2007.09.004, IF 2.8
  • Vanadium-Catalyzed Selective Oxidation of Alcohols to Aldehydes and Ketones with t-BuO2H, L. Rout and T. Punniyamurthy, Adv. Synth. Catal.2007, 349, 846, 10.1002/adsc.200600397, IF 5.6
  • Silica-Supported Vanadium-Catalyzed N-Oxidation of Tertiary Amines with Aq. H2O2. L. Rout and T. Punniyamurthy, Adv. Synth. Catal.2005, 347, 1958, 10.1002/adsc.200505166, IF 5.6

  • 04 PhD completed
  • 04 PhD Continuing
  • MPhil 07 Completed
  • MSc 71 Completed

  • DOS Approach for Synthesis of Sesquiterpene Anti-malaria Drugs: 2017-2020 (SERB/EMR/2016/006898)  SERB New Delhi, India 06 lakh , Completed
  • Synthetic Utility of Axial Chiral Allenes and Application in Natural Product Synthesis 2017-19, UGC-Start-UP-Grant-F-45(58)/2014, (BSR/FRP), UGC New Delhi, New Delhi, 00 lakh, Completed
  • Diversified Chiral Hemicotarnines For Future Cancer Drug, 2018-2021 27562800512017/20/1370/, S&T, S & T, Govt. of  Odisha, 16 lakh, Completed
  • Targeted drug delivery, 2021-24, 2016/LN/716/P/P &C. P & C, Govt. of Odisha  , 99 lakh Ongoing
  • Copper based bimetallic heterogeneous nano-catalyst for cross-coupling reaction 2021-24, CSIR/02(0393)/21/EMR-II,  01/04/2021-23, CSIR New Delhi, New Delhi, 27, 14,000/-, Ongoing
  • Hiyama cross-coupling of unactivated electrophiles and silanes using new catalytic system CRG/2022/001544, SERB New Delhi India, 45, 67,332/-, Ongoing
  • “DOS Approach for Sulfur Based Tetrahydroisoquinoline Anti-Cancer Drugs”,S&T-2587/ST/011/2023, S & T, Govt. of  Odisha, 10,00,000/-, Ongoing

MSc, MPhil, PhD, BS-MS

  • General Organic chemistry, Organic Spectroscopy, Retrosynthesis, Physical Organic Chemistry. Name reaction and rearrangement, Reagent and mechanism,  Advanced Organic Chemistry, Asymmetric Synthesis, Bio-organic Chemistry

Professional Membership:

  • American Chemical Society (ACS)
  • OCS Member, Orissa Chemical Society (Patron Member)
  • Royal Society of Chemistry (RSC)
  • French Medical Society (FMS/SCT)
  • Chemical Research Society of India (CRSI) Life member
  • Humboldt society, Germany

Editorial Member:

  • Cancer Biology and Therapeutic Oncology.
  • Current Organic Catalysis
  • Journal of Medicines Development Sciences